Gut microbiome may shape healthy aging, experts say:

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Key FactsGut microbiome may support healthy ageing

Sep 27, 2025 · Reading time: ~45 sec.
Summary created with AI assistance · Source: newscientist.com

Microbial diversity is considered important, often declines with age, and is influenced by diet, medication and social interaction.

With age, short-chain-fatty-acid-producing microbes decrease while pro-inflammatory microbes increase; this imbalance may contribute to chronic inflammation.

A 2023 study of 1,575 people found those aged 100 to 117 had more diverse, younger-like microbiomes; researchers suspect a longevity link.

Among 50 nursing-home residents, a daily prebiotic improved frailty measures over 13 weeks compared with a placebo.

"This imbalance is thought to contribute to chronic, low-grade inflammation, a state known as inflammaging, which is associated with higher risk of conditions such as cardiovascular disease, dementia and stroke," says Jessica Schneider, chief scientific officer at Corundum Systems Biology, a company in Tokyo, Japan, that invests in research.— Jessica Schneider, chief scientific officer at Corundum Systems Biology, Tokyo, Japan